During perimenopause, women may experience physical and psychological discomfort due to fluctuations or decreased levels of sex hormones. In addition to menstrual disorders such as irregular menstrual cycles, delayed menstruation, and increasing or decreasing menstrual volume until menopause, the main symptoms include a series of vasoconstrictive and neuropsychiatric symptoms, such as hot flashes, sweating, irritability, anxiety, emotional, palpitations, and insomnia. These are the perimenopausal syndrome, also commonly known as menopausal syndrome.

Thyroid hormones play a crucial role in the regulation of many body functions, including metabolism, growth, and development. The thyroid gland produces two main hormones, triiodothyronine (T3) and thyroxine (T4), which are released into the bloodstream and transported throughout the body. These hormones bind to specific receptors in cells and tissues, where they regulate gene expression and cellular activity.