CRP/SAA: Test immediately after sampling, get the result in 10 minutes，Revolutionary means of infection detection for clinic doctor.
1. About CRP(C-reactive protein)+SAA(Serum Amyloid A Protein )
For the colds and fever caused by the high incidence of respiratory infection, the infections caused by different pathogens have different characteristics, early differential diagnosis of infectious diseases can help clinicians to more quickly and accurately treat different types of infections.
Although the common respiratory rapid test such as antibody/antigen test has been widely used to identify the pathogens, but it is limited to some common pathogens. And the sensitivity of some antigen test is low. While antibody test is affected by the time the body produces antibodies and the body's immune function, and cannot reflect the severity of the disease.
In recent years, the value of serological inflammatory markers in the diagnosis and treatment of infectious diseases has been widely recognized internationally because they can be detected at the early stage of infection and can well reflect the severity and dynamic changes of the disease.
C-reactive protein (CRP) is synthesized by liver cells. When the body is infected or tissues are damaged, CRP levels can rise rapidly within hours of the onset of acute inflammation, and the increase is positively correlated with the degree of infection. It is a widely used inflammatory marker that can be used to evaluate tissue damage and inflammatory diseases, providing reference information for diagnosis, treatment and monitoring of diseases.
Serum amyloid A (hereinafter referred to as SAA) is an acute phase protein, and its concentration in the blood can increase dramatically within hours in inflammatory, infectious and non-infectious diseases. The increase can be 10-1000 times higher than normal. After the removal of pathogens, it can be quickly reduced to the normal level, which is a sensitive indicator reflecting the body's infection status and inflammation recovery. Similar to CRP, the test for SAA helps diagnose inflammation, monitor its activity and treatment, and is more persuasive than CRP in diagnosing viral infections.
2. Clinical significance of the combined CRP+SAA test
In the early diagnosis of infectious diseases, the combined SAA + CRP test can provide powerful data for the differential diagnosis of early bacterial and viral infections, and improve the specificity and sensitivity of diagnosis. Its clinical significance are as follows:
1) Auxiliary diagnosis:
The combined CRP +SAA test is a specific indicator for early diagnosis of viral infection, helping doctors to more quickly and accurately distinguish the type of infection and assess the degree of inflammation.
Clinical suggestions of the combined SAA + CRP test results in acute stage of infection
| SAA concentration | CRP concentration | Clinical suggestions |
| ＜10mg/L | Within normal reference interval | No acute stage inflammation |
| 10-100 mg/L | Normal or slight elevation | Virus infection(Mild Case) |
| 100-500mg/L | ＞50mg/L | Bacterial infection, Observe SAA and CRP level dynamically to evaluate the therapeutic effect |
| ≥500mg/L | Elevation but ≤50mg/L | Virus infection(severe case), Bacterial infection, recheck 12-24 hours later |
3)Guide treatment
Monitoring CRP and SAA levels can help doctors assess the effectiveness of treatment and changes in the patient's condition. Based on the test results, doctors can adjust the treatment plan and take the necessary measures in time to improve the treatment effect.
3) Prognosis assessment:
High levels of CRP and SAA are often associated with disease severity and prognosis, and can be used to assess patients' disease severity and prognostic risk.
4) Reduce unnecessary medication:
Through CRP and SAA tests, you can more accurately determine whether a patient is present with infection or inflammation, and avoid unnecessary antibiotic or anti-inflammatory drug use. This can help reduce drug abuse and the development of drug resistance, and protect patients from adverse drug reactions
5) Improve diagnostic accuracy:
The accuracy and comprehensiveness of diagnosis can be improved by combining CRP and SAA test results with clinical manifestations and other examination results. This helps doctors to have a more comprehensive understanding of patients' conditions, formulate more reasonable diagnosis and treatment plans, and improve diagnosis and treatment level and patient satisfaction.
3. CRP+SAA clinical application suggestions
4. CRP/SAA rapid test kit:
