Increased transmission of monkeypox virus requires increased air defenses
World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus declared on the 14th that the monkeypox outbreak constitutes a "public health emergency of international concern", which is also the highest level of global epidemic alert under the framework of the International Health Regulations.
A new, deadlier strain of the monkeypox virus is spreading rapidly in the Democratic Republic of Congo and has spread to neighboring countries that have never reported monkeypox cases, including Burundi, Kenya, Rwanda and Uganda.
Monkeypox A viral zoonotic disease caused by the monkeypox virus. Monkeypox virus (Monkeypox virus) is a double-stranded DNA enveloped virus, belonging to the same genus orthopoxvirus as variola virus, with a sequence consistency of 96.31%. It can be transmitted from animals to humans through direct close contact, and can also be transmitted from person to person, mainly through blood, body fluids, respiratory droplets, mucus, etc., but it requires close contact with infected people.
After decades of transmission, the current monkeypox virus can be divided into Clade I (Central African clade) and Clade Ⅱa and Clade Ⅱb (West African clade) clades. The clinical symptoms caused by Clade I branch were severe and the fatality rate reached 10%. Clade II was milder, with a fatality rate of 3.6%. Associated with the latest outbreak is the Clade I branch!
The symptoms of monkeypox virus infection are similar to those of smallpox, but the clinical severity is less severe and the incubation period is usually 6 to 13 days, and may be as long as 21 days. The initial symptoms of monkeypox in humans include fever, headache, muscle aches, back pain and swollen lymph nodes, which can progress to a widespread rash on the face and body. Most people recover within a few weeks, but some people become seriously ill or even die.
At present, there is no vaccine or specific drug for monkeypox in the world. However, due to the similar antigenicity of smallpox virus, smallpox vaccine can also provide up to 85% protection against monkeypox. For monkeypox treatment, mainly supportive treatment, symptomatic treatment and control of secondary infection. Although several classes of traditional antivirals for smallpox, including Cidofovir, Brincidofovir and Tecovirimat, have been shown to have some therapeutic effect in cell culture, animal experiments and a small number of cases, the efficacy and safety of a large number of people still need to be further explored.
Speeding up screening and diagnosis is an important measure to block transmission and reduce monkeypox mortality! Who is working with national authorities and vaccine manufacturers to explore potential vaccine donations, and coordinating with partners to promote equitable access to vaccines, treatments, diagnostic tools and other resources.
WIZ independently developed monkeypox virus nucleic acid detection kit (fluorescent real-time PCR method). The reagent detects the specific gene fragments of monkeypox virus by real-time fluorescent PCR, which can accurately identify monkeypox virus and help the accurate diagnosis and prevention and control of related diseases. The reagent has the advantages of high sensitivity and good specificity, and can detect the virus in low concentration in the sample, and obtain the detection result quickly. Monkeypox virus nucleic acid detection provides molecular diagnostic basis for monkeypox virus infection, and realizes early and rapid diagnosis of suspected infected persons.
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