Application of calprotenin combined with fecal occult blood test in colorectal cancer screening
Colorectal cancer is one of the most common malignant tumors and its incidence is increasing year by year. Early detection of colorectal cancer is crucial for treatment and prognosis, so screening has become one of the important means to prevent colorectal cancer. At present, the commonly used colorectal cancer screening methods include colonoscopy, stool occult blood test and so on. However, colonoscopy is expensive, cumbersome, and somewhat invasive, limiting its use in mass screening. Therefore, it is of great significance to find a simple and accurate screening method for the early detection of colorectal cancer.
Calprotenin is a heterodimer protein rich in neutrophils, and its correlation with colorectal cancer has been studied. Multiple studies have shown that elevated levels of calprotenin indicate active inflammation in the body and are often associated with inflammatory bowel diseases including Crohn's disease and ulcerative colitis. Inflammation can promote the occurrence and development of cancer and plays a role in various steps of tumor cell transformation, proliferation, invasion, angiogenesis and metastasis.
Fecal occult blood test is one of the commonly used colorectal cancer screening methods, which detects occult blood in the stool to screen for colorectal cancer. However, fecal occult blood test has a certain false positive rate and false negative rate, which affects its accuracy in screening. Calprotenin combined with fecal occult blood test can make up for the deficiency of fecal occult blood test and improve the accuracy of screening.
Studies have shown that calprotenin combined with fecal occult blood test can help increase sensitivity, specificity and accuracy in colorectal cancer screening, which can help early detection of patients and timely treatment. In clinical practice, calprotenin combined with fecal occult blood test has been used in colorectal cancer screening. In the future, with the continuous progress of technology and in-depth research, the application prospect of calprotenin combined with fecal occult blood detection in colorectal cancer screening will be broader.
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