Clinical Significance of Fecal Calprotectin (FC) Testing
Calprotectin belongs to the S100 protein family and is a heterozygous calcium-binding protein with a molecular weight of 36kDa. It is present in the cytoplasm of neutrophils. Calprotectin is quite stable, and fecal calprotectin (FC) can remain stable at room temperature for 7 days, making it a reliable marker for monitoring intestinal inflammation.
Elevated levels of fecal calprotectin are associated with active inflammatory bowel disease (IBD) such as Crohn’s disease or ulcerative colitis and have been included in the guidelines for IBD in China. Fecal calprotectin testing can help clinicians differentiate between inflammatory and non-inflammatory bowel diseases in the lower gastrointestinal tract, such as irritable bowel syndrome (IBS). It can also be used to assess disease activity and evaluate treatment effectiveness and predict relapse in IBD patients. Additionally, it has some value in colon cancer screening and differentiating diarrhea causes. The clinical significance can be summarized as follows:
(1) Differentiating the IBD and IBS;
(2) Monitoring the IBD progression;
(3) Evaluating the treatment effectiveness and mucosal healing, guiding proper medicine applying;
(4) Predicting IBD relapse;
(5) Differentiating whether it is bacterial or viral diarrhea;
(6) Being able to screen the colorectal cancer together with fecal occult blood test.
Wizbiotech, as a POCT company with over ten years experience in the field of gastrointestinal diseases, had developed a calprotectin testing kit and had obtained relevant registration certificates. It is widely used in hospitals, clinics, and other medical institutions, receiving a lot of positive market feedback, many doctors and patients recognize the quality and service of Wizbiotech’s and choose to use WIZ’s calprotectin testing kit. If you need calprotectin products, please contact our sales team!
